When To Use Anti Obesity Medications?

WHEN TO USE AOM??

  • HUNGER CONTROL, PORTION CONTROL - GLP1’s - Saxenda, Ozempic, Wegovy, Mounjaro
  • SNACKING AND CRAVING - Contrave
  • SWEET CRAVING AND FATIGUE- Phentermine 
  • SWEET CRAVING / HEADACHES- Topiramate 
  • WEIGHT REGAIN FROM MENTAL HEALTH MEDICATIONS -Metformin


GLP1 AGONIST MEDICATIONS-INDICATIONS FOR USE

  • BMI>27 WITH COMORBIDITIES OR BMI>30 WITH NO COMORBIDITIES
  • Not a candidate for surgery
  • Preoperatively for BMI>60
  • Within 3months Weight Loss Surgery if not on expected weight loss curve
  • Weight regain post Weight Loss Surgery


TABLETS:

Duromine (Phentermine)

  • Dosage: 15–30 mg weekly
  • Not PBS listed
  • Expected weight loss: 5–10% total weight loss over 12 weeks (Kang et al. 2010)


Contrave (Naltrexone/Bupropion)

  • Dosage: 8 mg/90 mg daily, increasing up to 4 tablets per day
  • Not PBS listed
  • Expected weight loss: 5.4% total weight loss over 56 weeks (Greenway et al. 2010)


Topamax (Topiramate)

  • Dosage: 25–200 mg daily
  • TGA approved for migraines and epilepsy, not PBS listed for weight loss
  • Expected weight loss: 5% total weight loss over 24 weeks (Bray et al. 2003)


INJECTABLE MEDICATIONS:

Mounjaro (Tirzepatide)

  • Dosage: 2.5–15 mg weekly
  • TGA approved for type 2 diabetes, not PBS listed for weight loss
  • Expected weight loss: 15–20.9% total weight loss over 72 weeks (Surmount Trials)


Wegovy (Semaglutide)

  • Dosage: 0.25–2.4 mg weekly
  • TGA approved for weight loss, not PBS listed
  • Expected weight loss: 14.9–18.5% total weight loss over 68–208 weeks (Step 1–4, 5, 8, and Select Trials)


Ozempic (Semaglutide)

  • Dosage: 0.25–1 mg weekly
  • PBS listed for type 2 diabetes, not PBS listed for weight loss
  • Expected weight loss: 6.5% total weight loss over 40 weeks (Sustain 7 Trials)


Saxenda (Liraglutide)

  • Dosage: 0.6–3 mg daily
  • TGA approved for weight loss, not PBS listed for weight loss
  • Expected weight loss: 6.4–8% total weight loss over 56–68 weeks (Step 8, Scale, and Leader Trials)


Trulicity (Dulaglutide)

  • Dosage: 1.5 mg weekly
  • TGA approved for weight loss, PBS listed for type 2 diabetes
  • Expected weight loss: 3% total weight loss over 40 weeks (Sustain 7 Trials)